We certainly could! I think I would like to do that for a start with Anna-Liza. I can always continue her story afterwards if I decide to. She comes with the Perceptive trait which is perfect, but needs lifetime happiness to change her current LTW of becoming a Star News Anchor in the journalism career, which I doubt she will achieve anyway since she is retired from that career when you begin the game. This old lady has some interesting quirks though. I just love her.
What would be the rules of the playthrough? I play with store items and mods, but nothing which could affect job/work-related gameplay. She also comes with some skill points here and there. I guess I could redo her with MC or by making her anew, but her starting relations are kinda part of her story, so I'm a bit loathe to go drastic.